Bioventix plc 

(“Bioventix” or “the Company”) 

Director Dealing 

 

Bioventix plc (BVXP), a UK company specialising in the development and commercial supply of high-affinity monoclonal antibodies for applications in clinical diagnostics, announces that the Company was notified on 30 October 2024 that on 30 October 2024 Bruce Hiscock, Chief Financial Officer of the Company, purchased a total of 300 ordinary shares of 5 pence each in the Company (“Ordinary Shares”), at an average price of 3,330 pence per Ordinary Share (the “Purchase”).

 

Following the Purchase, Bruce Hiscock has a beneficial interest in 1,089 Ordinary Shares, representing approximately 0.01 per cent. of the issued share capital of the Company. 

 

The notification below, made in accordance with the requirements of the EU Market Abuse Regulation, provides further details. 

 

 

For further information please contact: 

 

Bioventix plc 

Peter Harrison 

 

Chief Executive Officer 

Tel: 01252 728 001 

Cavendish 

Geoff Nash / Abigail Kelly

Nigel Birks / Harriet Ward 

 

Corporate Finance 

ECM 

Tel: 020 7220 0500 

 

 

Notification and public disclosure of transactions by persons discharging managerial responsibilities and persons closely associated with them 

  

1 

Details of the person discharging managerial responsibilities / person closely associated 

a) 

Name 

Bruce Hiscock 

2. 

Reason for the Notification 

a) 

Position/status 

Chief Financial Officer 

b) 

Initial notification/Amendment 

Initial notification 

3. 

Details of the issuer, emission allowance market participant, auction platform, auctioneer or auction monitor 

a) 

Name 

Bioventix Plc 

b) 

LEI 

213800225MHX7LZQY108 

4. 

Details of the transaction(s): section to be repeated for (i) each type of instrument; (ii) each type of transaction; (iii) each date; and (iv) each place where transactions have been conducted 

a) 

Description of the Financial instrument, type of instrument 

Ordinary Shares of 5 pence each 

Identification code 

GB00B4QVDF07 

b) 

Nature of the transaction 

Purchase of Ordinary Shares 

c) 

Price(s) and volume(s) 

300 Ordinary Shares 

3,330 pence 

d) 

Aggregated information: 

 

·     Aggregated volume 

 

·     Price 

Purchase of 300 Ordinary Shares at 3,330 pence each 

e) 

Date of the transaction 

30 October 2024 

f) 

Place of the transaction 

London Stock Exchange, AIM Market (XLON) 

 

Director’s report and financial statements for the year ended 30th June 2024.

To download this report as a PDF file click here.

Notification of major interest in shares. To download this report as a PDF file click here.

Abstract

Polycylic Aromatic Hydrocarbons (PAHs) are produced during the incomplete burning of organic materials. PAH sources include vehicle exhaust, tobacco smoke and waste incineration. Environmental and occupational exposures to PAHs are known to occur. Cancer is a significant endpoint of PAH exposure and several occupations associated with high PAH exposure have been classified by IARC as carcinogenic to humans (Group 1).

Pyrene is a common component of PAH mixtures and metabolism of pyrene leads to the excretion of 1-hydroxypyrene glucuronide (1-OHPyrG) in urine. Laboratory measurement of urinary 1-OHPyrG is employed in occupational and environmental biomonitoring programmes. The production of an anti-1-OHPyrG monoclonal antibody would allow the development of a PAH biomonitoring ELISA facilitating large scale laboratory screening and routine testing.

The development of a lateral flow immunoassay and the production of a field test (point of use test) would greatly increase the value of biomonitoring. A novel Lateral Flow has been developed which employs an anti-1-OHPyrG sheep monoclonal antibody (Mab) to capture the PAH metabolite. The captured metabolite is visualised through a second Mab raised against the Mab-1-OHPyrG immune complex. This sandwich assay provides a positive correlation between the assay signal and biomarker concentration.

A Smartphone camera allows signal measurement and a carefully considered ‘app’ provides result interpretation and data analysis. Results are provided in an exposed/not-exposed format. Performance of the lateral flow was confirmed through a comparative study and field trial. The development of a lateral flow test provides “realtime” analysis to occupational health professionals. On-site screening allows the immediate confirmation of safe working practice, provides immediate reassurance to those involved in potentially hazardous activities and greatly increases the efficacy of biomonitoring.

Bioventix plc

(“Bioventix” or “the Company”)

Director Dealing

 

Bioventix plc (BVXP), a UK company specialising in the development and commercial supply of high-affinity monoclonal antibodies for applications in clinical diagnostics, announces that on 29 April 2024 Bruce Hiscock, Chief Financial Officer of the Company, purchased a total of 11 ordinary shares of 5 pence each in the Company (“Ordinary Shares”), at an average price of 4,452 pence per Ordinary Share (the “Purchase”). The Ordinary Shares were purchased under a dividend reinvestment plan (“DRIP”).

 

Following the Purchase, Bruce Hiscock has a beneficial interest in 789 Ordinary Shares, representing approximately 0.01 per cent. of the issued share capital of the Company.

 

The notification below, made in accordance with the requirements of the EU Market Abuse Regulation, provides further details.

 

For further information please contact:

Bioventix plc

Peter Harrison

 

Chief Executive Officer

Tel: 01252 728 001
Cavendish

Geoff Nash / Simon Hicks

Nigel Birks / Harriet Ward

 

Corporate Finance

ECM

Tel: 020 7220 0500

 

Notification and public disclosure of transactions by persons discharging managerial responsibilities and persons closely associated with them

1 Details of the person discharging managerial responsibilities / person closely associated
a) Name Bruce Hiscock
2. Reason for the Notification
a) Position/status Chief Financial Officer
b) Initial notification/Amendment Initial notification
3. Details of the issuer, emission allowance market participant, auction platform, auctioneer or auction monitor
a) Name Bioventix Plc
b) LEI 213800225MHX7LZQY108
4. Details of the transaction(s): section to be repeated for (i) each type of instrument; (ii) each type of transaction; (iii) each date; and (iv) each place where transactions have been conducted
a) Description of the Financial instrument, type of instrument Ordinary Shares of 5 pence each
Identification code GB00B4QVDF07
b) Nature of the transaction Purchase of Ordinary Shares
c) Price(s) and volume(s) 11 Ordinary Shares

4,552 pence

d) Aggregated information:

 

·     Aggregated volume

 

·     Price

Purchase of 11 Ordinary Shares at 4,452 pence each
e) Date of the transaction 29 April 2024
f) Place of the transaction London Stock Exchange, AIM Market (XLON)

 

TR-1: Notification of major interest in shares. To download this report as a PDF file click here.

Abstract

Objectives
To investigate whether circulating acute-phase brain-derived tau (BD-tau) is associated with functional outcome after ischemic stroke.

Methods
Plasma tau was measured by a novel assay that selectively quantifies BD-tau in the Sahlgrenska Academy Study on Ischemic Stroke (SAHLSIS), which includes adult cases with ischemic stroke and controls younger than 70 years, and in an independent cohort of adult cases of all ages (SAHLSIS2). Associations with unfavorable 3-month functional outcome (modified Rankin scale score >2) were analyzed by logistic regression. Various stratified and sensitivity analyses were performed, for example, by age, stroke severity, recanalization therapy, and etiologic subtype.

Results
This study included 454 and 364 cases from the SAHLSIS and SAHLSIS2, with a median age of 58 and 68 years, respectively. Higher acute BD-tau concentrations were significantly associated with increased odds of unfavorable outcome after adjustment for age, sex, day of blood draw, and stroke severity (NIH stroke scale score) in both cohorts (OR per doubling of BD-tau: 2.9 [95% CI 2.2–3.7], P = 1 × 10−15 and 1.8 [1.5–2.2], P = 7 × 10−9, respectively). The association was consistent in the different stratified and sensitivity analyses.

Discussion
BD-tau is a promising blood-based biomarker of ischemic stroke outcomes, and future studies in larger cohorts are warranted.

Interim Report and Financial Statements for the 6 months to 31 December 2023

 

To download this report as a PDF file click here.

Abstract

Staging amyloid-beta (Aβ) pathophysiology according to the intensity of neurodegeneration could identify individuals at risk for cognitive decline in Alzheimer’s disease (AD). In blood, phosphorylated tau (p-tau) associates with Aβ pathophysiology but an AD-type neurodegeneration biomarker has been lacking. In this multicenter study (n = 1076), we show that brain-derived tau (BD-tau) in blood increases according to concomitant Aβ (“A”) and neurodegeneration (“N”) abnormalities (determined using cerebrospinal fluid biomarkers); We used blood-based A/N biomarkers to profile the participants in this study; individuals with blood-based p-tau+/BD-tau+ profiles had the fastest cognitive decline and atrophy rates, irrespective of the baseline cognitive status. Furthermore, BD-tau showed no or much weaker correlations with age, renal function, other comorbidities/risk factors and self-identified race/ethnicity, compared with other blood biomarkers. Here we show that blood-based BD-tau is a biomarker for identifying Aβ-positive individuals at risk of short-term cognitive decline and atrophy, with implications for clinical trials and implementation of anti-Aβ therapies.

Abstract

Blood phosphorylated tau (p-tau) biomarkers, including p-tau217, show high associations with Alzheimer’s disease (AD) neuropathologic change and clinical stage. Certain plasma p-tau217 assays recognize tau forms phosphorylated additionally at threonine-212, but the contribution of p-tau212 alone to AD is unknown. We developed a blood-based immunoassay that is specific to p-tau212 without cross-reactivity to p-tau217. Here, we examined the diagnostic utility of plasma p-tau212. In five cohorts (n = 388 participants), plasma p-tau212 showed high performances for AD diagnosis and for the detection of both amyloid and tau pathology, including at autopsy as well as in memory clinic populations. The diagnostic accuracy and fold changes of plasma p-tau212 were similar to those for p-tau217 but higher than p-tau181 and p-tau231. Immunofluorescent staining of brain tissue slices showed prominent p-tau212 reactivity in neurofibrillary tangles that co-localized with p-tau217 and p-tau202/205. These findings support plasma p-tau212 as a peripherally accessible biomarker of AD pathophysiology.